RESEARCH TO DESIGN

Research-Informed Design

Brainlume applies principles from transcranial photobiomodulation (tPBM) research through four connected design choices.

810nm NIR

A near-infrared wavelength used in research on light transmission and cellular energy.

Scalp-Level Delivery

Six light windows direct near-infrared light toward the scalp.

Non-Thermal PBM

Light delivery based on photobiological processes rather than tissue heating.

10Hz Alpha / 40Hz Gamma

Two pulse frequencies, both operating at a 50% duty cycle.

WAVELENGTH & LIGHT DELIVERY

Why 810nm?

810nm near-infrared light is used in tPBM research to study light transmission through head tissues and interactions with cellular energy pathways.

Only a portion of surface light passes through scalp and skull. Transmission depends on tissue and delivery conditions.

  • Tissue transmission
  • Mitochondrial research
  • Brain-focused PBM
810nm · Invisible near-infrared light
Wavelength in nanometers. Colors are illustrative; near-infrared light is invisible to the human eye.

CELLULAR ENERGY RESEARCH

Light & Cellular Energy

Mitochondria produce usable cellular energy through ATP-related processes. Photobiomodulation research examines how near-infrared light interacts with cytochrome c oxidase and other pathways involved in mitochondrial function.

Researchers also study oxygen use, nitric oxide signaling and hemodynamic responses. These connected processes help explain the scientific rationale for brain-focused light delivery.

Mitochondria & CCO

Studies examine cytochrome c oxidase and other pathways associated with mitochondrial function.

ATP & Oxygen Use

Researchers measure energy metabolism and oxygen use to investigate responses to light.

Nitric Oxide Signaling

NO-related signaling and hemodynamics are additional areas of PBM research.

OPTICAL DESIGN & DOSIMETRY

Brainlume Design Transparency

Explore the wavelength, pulse settings and optical dose behind Brainlume.

Optical output and calculated 20-minute exposure at the delivery windows.
Parameter Why It Matters Our Specification
Wavelength Identifies the near-infrared wavelength used by the LEDs. 810nm ± 5nm
Pulse Settings Defines pulse frequency and the proportion of each cycle with the LEDs ON. 10Hz / 40Hz50% duty cycle
Output / Window Distinguishes peak optical power from average power over a full pulse cycle. Peak ≈180mWAvg. ≈90mW
Spot Size Defines the area used to calculate irradiance and exposure. Diameter ≈11.5mmArea ≈1.04cm²
Irradiance Expresses optical power per unit area at the light-delivery surface. Avg. ≈86.5mW/cm²Peak ≈173mW/cm²
Exposure / Window Expresses optical energy per unit area over a 20-minute session. ≈103.8J/cm² in 20 minutes

Values describe emitted light at the delivery windows. Average values include the full pulse cycle; exposure is calculated per window over 20 minutes.

Parameters are shown for design transparency and are not medical or therapeutic outcome claims.

EXPLORE THE EVIDENCE

Selected Research

These independent studies explore PBM mechanisms and human responses.

Human Studies

810nm LED Pulse Frequency & EEG

2021 · Journal of Innovative Optical Health Sciences

  • Human study
  • 810nm LED
  • EEG

An 810nm LED study compared forehead illumination at different pulse frequencies and measured changes in EEG activity.

Tested 0, 5, 10 and 20Hz; the protocol did not test 40Hz.

Reference details

Full title: Effects of stimulating frequency of NIR LEDs light irradiation on forehead as quantified by EEG measurements

Study context: This study was not conducted on Brainlume and should not be interpreted as proof of a specific wellness result.

View Study (opens in a new tab)

Wavelength, Placement & Prefrontal Responses

2023 · Neurophotonics

  • Human study
  • 800/850nm laser
  • NIRS

Researchers compared wavelengths and forehead sites using near-infrared spectroscopy to assess prefrontal connectivity and coupling.

Used 800/850nm lasers and different delivery conditions from Brainlume.

Reference details

Full title: Site-specific effects of 800- and 850-nm forehead transcranial photobiomodulation on prefrontal bilateral connectivity and unilateral coupling in young adults

Study context: This study used 800nm and 850nm light, not Brainlume's exact 810nm design. It supports the broader wavelength and placement rationale, not a direct Brainlume product claim.

View Study (opens in a new tab)

Repeated LED tPBM, Vigilance & EEG Networks

2023 · Bioengineering

  • Human study
  • LED
  • Repeated use

Repeated LED-based tPBM was studied in healthy adults using vigilance performance and EEG network measures.

Independent LED device and repeated-use protocol; results are not Brainlume-specific.

Reference details

Full title: Repeated Transcranial Photobiomodulation with Light-Emitting Diodes Improves Psychomotor Vigilance and EEG Networks of the Human Brain

Study context: This study supports the broader research direction of repeated tPBM use. It does not guarantee that every Brainlume user will experience the same outcome.

View Study (opens in a new tab)

Mechanisms

Brain PBM: Mechanisms & Research Overview

2018 · Molecular Neurobiology

  • Narrative review
  • Mechanisms
  • Brain PBM

A narrative review of mitochondrial, vascular and other biological pathways investigated in brain photobiomodulation.

Reviews multiple experimental models and devices, rather than a Brainlume product study.

Reference details

Full title: Brain Photobiomodulation Therapy: a Narrative Review

Study context: This is a broad review, not a Brainlume product study. It should be used to explain scientific background, not to promise a specific user result.

View Study (opens in a new tab)

CCO & Hemodynamic Responses to Light

2017 · Journal of Cerebral Blood Flow & Metabolism

  • Human study
  • 1064nm laser
  • CCO

Broadband NIRS measured cytochrome-c-oxidase and hemodynamic responses during transcranial infrared laser stimulation.

Used a 1064nm laser, not Brainlume’s 810nm LED design.

Reference details

Full title: Up-regulation of cerebral cytochrome-c-oxidase and hemodynamics by transcranial infrared laser stimulation: A broadband near-infrared spectroscopy study

Study context: This study used 1064nm infrared laser stimulation, not Brainlume's 810nm wearable design. It is relevant as mechanism-direction evidence, not as direct Brainlume proof.

View Study (opens in a new tab)

Light, Mitochondria & Cerebrovascular Responses

2021 · Brain Stimulation

  • Human study
  • 1064nm laser
  • Metabolism

Researchers studied mitochondrial and cerebrovascular responses to infrared laser stimulation in younger and older healthy adults.

A human mechanism study using a 1064nm laser and a separate delivery protocol.

Reference details

Full title: Transcranial laser stimulation: Mitochondrial and cerebrovascular effects in younger and older healthy adults

Study context: This was not an 810nm Brainlume study. It should be presented as broader human mechanism evidence with wavelength and device differences clearly noted.

View Study (opens in a new tab)

Reviews

Human tPBM & Cognitive Research

2023 · Ageing Research Reviews

  • Systematic review
  • Human studies
  • Cognition

A systematic review of human tPBM studies covering learning, memory, attention and other cognitive measures.

Includes varied populations, wavelengths, devices and study protocols.

Reference details

Full title: Can transcranial photobiomodulation improve cognitive function? A systematic review of human studies

Study context: This review includes different populations, wavelengths, devices, and study designs. It should not be read as a Brainlume-specific clinical claim or a guarantee of cognitive improvement.

View Study (opens in a new tab)

Human Brain Activity Under tPBM

2023 · Reviews in the Neurosciences

  • Systematic review
  • EEG
  • Brain imaging

A systematic review of human brain-activity findings measured with EEG and other neurophysiological methods.

Summarizes the research field; it does not validate a specific Brainlume outcome.

Reference details

Full title: A systematic review of the effects of transcranial photobiomodulation on brain activity in humans

Study context: This review supports the broader scientific basis for studying brain activity under tPBM. It does not prove that Brainlume produces a specific effect for every user.

View Study (opens in a new tab)

Photobiomodulation in the Brain

2019 · Academic Press · Edited book

  • Reference book
  • Mechanisms
  • Neuroscience

An edited reference book covering brain PBM mechanisms, experimental methods and research across neuroscience.

A 2019 academic book, rather than a 2021 journal article or Brainlume trial.

Reference details

Full title: Photobiomodulation in the Brain: Low-Level Laser (Light) Therapy in Neurology and Neuroscience

Study context: This is a field overview, not a consumer wellness product study. Any disease-related discussion should not be translated into Brainlume marketing claims.

View Reference (opens in a new tab)

These references are provided for educational purposes. Individual experiences may vary.

Brainlume device
BRING LIGHT INTO YOUR ROUTINE

Continue Exploring Brainlume

Explore Brainlume’s 810nm headset and build your daily light routine.